Two weeks have passed since the events of the Hangman Returns. The vampire slayer, Jericho Caine, and the demon hunter, Father Tom Padilla, the Death Brothers, return to The Reefs in the Gulf of Mexico to settle a score with the vampire sirens. However, a female angel, Sariel, with romantic intentions toward Jericho, plans to separate the brothers and seduce the slayer. Sariel strikes a deal with the half-demon Hangman to help. She also enlists the services of a mad scientist to use is creation, Thaden, a hybrid vampire/werewolf to kill Tom. All plotlines converge into a final showdown on a farm in the middle of nowhere.
