Lords of Dyscrasia explores the choices humans and their gods make as a disease corrupts their souls, shared blood, and creative energies. Historically, dyscrasia referred to any imbalance of the four medicinal humors professed by the ancient Greeks to sustain life. Lords of Dyscrasia presents them as spiritual muses for artisans, sources of magical power, and contagions of a deadly disease.
Dyscrasia plagues the insectan elders of the underworld. Desperate to save them from extinction, the golem Doctor Grave infuses the soul of his dying queen into the blood of a human artisan, Lord Ante Lysis. Her soul passes through Ante's blood into his offspring, thus the Lysis bloodline carries the diseased queen's soul as the doctor perfects the necromancy needed to resurrect her. But the last descendant of Ante is determined to quench the queen's soul and journeys to the underworld to do so....