In 1562, Michel de Nostradamus led a small party on an expedition deep into the hostile Desert of Barbary, now known as the Sahara. Without any knowledge of what they might find, the small party entered the vast desert in search of a miracle.
In the present day, Dr. Zara Delacroix enlists the help of Sam Reilly to hunt for answers about a book she believes was buried in the Sahara centuries earlier to protect humanity from some great catastrophe. This ancient manuscript was named The Book of Nostradamus.