When a genetically modified tarantula finds itself loose in the Great White shark exhibit at Shark World, the feisty arachnid sinks its fangs into the main attraction. Without warning, the Great White mutates into Sharkantula and the opening day show turns deadly. The mutated shark/tarantula hybrid is hungry and ready to feast upon the flesh of those that don't run away fast enough to escape her webbing. Desperate to stop the carnage, a group of Shark World employees join forces with the tarantula's keeper in an effort to stop the devastation before Sharkantula can escape the confines of the aquatic theme park and spread her terror across the United States.